//m.karmaimpex.com/jhcr Heighpubs开放获必威体育西汉姆联取期刊上 en - us 06/04/2021//m.karmaimpex.com/jhcr/jhcr-aid1017.php & lt; h2> Abstract< / h2><p>Background: Leukemia is frequently associated with fundoscopic abnormalities. However, no organized effort has been made for analyzing leukemic retinopathy in our country. This study was done to observe the demographic profile and correlation between fundoscopic findings of retinal exudates and hematological parameters in leukemic patients.</p> <p>Materials and Methods: The study was a hospital-based descriptive cross-sectional study among 50 leukemic patients in Medicine and Oncology departments of Bangladesh Medical College and Hospital (BMCH) from May, 2020 to October, 2020. Fundoscopic examination was done which was reviewed by an ophthalmologist. Collected data was analyzed statistically by using SPSS-17 (Chicago, Illinois).</p> <p>Results: Among 50 leukemic patients&rsquo;, the fundal lesion was detected in 32 patients (64%), retinal exudates are rare. Only 3 patients (6%) had exudates while others (29 patients, 58%) have retinal hemorrhages. Exudates did not show any statistically significant relationship with types of leukemia (p value = 0.53). There was no statistically significant association between fundal exudates and high white cell count (p = 0.56) or low hemoglobin level (p = 0.11) or low platelet level (p = 0.11).</p> <p>Conclusion: This study has identified retinopathy occurring frequently in leukemic patients. Therefore, an adequate attention should be paid at fundoscopic evaluation while treating leukemic patients.</p> 04/07/2021//m.karmaimpex.com/jhcr/jhcr-aid1016.php & lt; h2> Abstract< / h2><p>Background: Like other viruses, the SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) appears to be responsible for several autoimmune complications. The occurrence of autoimmune hemolytic anemia has been described in several case reports. This AIHA was also noticeable by the important number of blood transfusions required for COVID-19 (coronavirus disease 2019) patients. By investigating RBC coating autoantibodies, this article attempts to clarify the autoimmune aspect of the anemia in the context of SARS-CoV-2 infection.</p> <p>Results: A large population of COVID-19 patients selected at Saint-Luc University Hospital showed an average of 44% DAT positivity. In this population, the intensive care patients were more prone to DAT positivity than the general ward patients (statistically significant result). The positive DAT appeared &laquo; transmissible &raquo; to other RBCs via COVID-19 DAT-positive patient&rsquo;s plasma.</p> <p>Conclusion: The strongest hypothesis explaining this observation is the targeting of cryptic antigens by autoantibodies in COVID-19 patients.</p> 02/10/2021//m.karmaimpex.com/jhcr/jhcr-aid1015.php <p>The complicated process of cancer triggers many physiological systems like vascular endothelial functions and hemostasis, which signifies the increased risk of thrombosis, which triggers thromboembolic events resulting in increased mortality and morbidity [1-3]. Tumorigenesis contributes by activation of coagulation around the perivascular region [4].</p> 12/30/2020//m.karmaimpex.com/jhcr/jhcr-aid1014.php <p>In general, Erythrocytes&nbsp;may&nbsp;referred to as corpuscle (Red Blood Cells).These erythrocytes&nbsp;will&nbsp;play&nbsp;a significant&nbsp;role in our body. It carries the&nbsp;element&nbsp;round the&nbsp;body&nbsp;and produce&nbsp;dioxide&nbsp;back to lungs.</p> 09/12/2019//m.karmaimpex.com/jhcr/jhcr-aid1013.php & lt; h2> Summary< / h2>& lt; p> & lt; strong>简介:& lt; / strong> Erdheim-Chester疾病(ECD)是一种罕见的和不能下放cult-to-treat non-Langerhans细胞组织细胞增生症的特点是过度生产和积累的组织细胞。这项研究报告的儿童早期开发,强调其诊断、评估和治疗的lt; br /比;疼痛与疾病相关联。;/ p>& lt; p> & lt; strong> Report< / strong>:六年前,一个39岁的男性病人,广义的中等强度的下肢疼痛相关的更大的强度与移动有关。组织细胞增生症的诊断与panhypopituitarism和肾上腺机能不全。特定的诊断,骨骼病变活检进行,揭示了存在的组织细胞的增殖CD1负,S100蛋白阳性和CD68负面。因此,non-Langerhans组织细胞增生症的诊断儿童早期开发确认。在接下来的两年,病人出现严重的骨痛,尤其是下肢和颅穹窿,疼痛消退在一定程度上使用曲马多和扑热息痛。因为疼痛,病人不能行走,成为卧床不起的病人仍在剧烈的疼痛,即使管理的吗啡,阿片类药物是由吗啡(60毫克/天)改为羟考酮(30毫克/天)为方便剂量; furthermore, the oxycodone dosage was scheduled to increase to 40mg/day that same week. The patient experienced significant pain reduction, requiring rescue analgesia only once or twice a week.</p> <p><strong>Conclusion</strong>: To the best of our knowledge, this is the first case report on the characterization and treatment of pain specific to ECD, and we highlight that the patient had a good response to treatment.</p> 09/02/2019//m.karmaimpex.com/jhcr/jhcr-aid1012.php & lt; h2> Abstract< / h2><p>Essential Thrombocythemia (ET) is currently classified as a Philadelphia negative myeloproliferative neoplasm (MPN) together with polycythemia vera (PV) and primary myelofibrosis (PMF); the latter can be further divided in pre-fibrotic primary myelofibrosis (pre-PMF) and overt myelofibrosis, as listed in the revised 2016 World Health Organization classification of myeloid malignancies (WHO 2016). Overall, respect to the others MPNs, ET is characterized by favorable prognosis, lower life expectancy if compared to the control population, increased risk of thrombohemorrhagic complications along with possible evolution in myelofibrosis and leukemic transformation. In this review the authors will review current knowledge on biology, clinical aspects, prognosis and stratification of thrombotic risk, therapeutic options and outcome in ET patients.</p> 08/08/2019//m.karmaimpex.com/jhcr/jhcr-aid1011.php & lt; h2> Abstract< / h2><p>In 1901, ABO system of blood groups was determined by Karl Landsteiner. It is present in different organisms like rodents, primates that includes chimpanzees, bonobos etc. The blood groups type in this system depends on some genes that are specific ABO gene. Arachnophobia is the dread of creepy crawlies and different creature like spiders. Individuals suffering from arachnophobia generally feels uneasy in any place where they accept that they could harbour arachnids or their existence for example, webs. 100 samples of blood from volunteers were used for Blood group test. The Blood groups were tested and results were recorded after the test all the used kits were discarded. The results shows that there is no clear cut difference between the arachnophobic males and non-arachnophobic male&rsquo;s percentages, so no relation found in males. Similarly, in females both phobic and non-phobic ladies have no differences in their result values so, no relation was found. Whereas, in case of arachnophobic males and females comparison no relation was found. So, there is no relationship between ABO blood group system and arachnophobia and there may be a relation between non-phobia and AB+, B+ blood group in males whereas, in females only B+ blood group have relation with non-phobia.</p> 07/15/2019//m.karmaimpex.com/jhcr/jhcr-aid1010.php & lt; h2> Abstract< / h2><p>Varicella zoster virus behaves differently from other herpes viruses as it differs from them in many aspects. Recently, there has been growing evidence on the beneficial effects of the virus in immune compromised hosts and these effects are translated into prolongation of survival. The reported beneficial effects of the virus include: (1) stimulation of bone marrow activity in patients with hematologic malignancies and bone marrow failure syndromes, (2) antitumor effects in various hematologic malignancies and solid tumors, and (3) association with graft versus host disease which has anticancer effects. Additionally, there are several reports on the safety of the live-attenuated even in severely immune suppressed individuals and on the emerging role of the virus in cancer immunotherapy. In this review, the following aspects of the virus will be thoroughly discussed: (1) new data on the genetic background, pathogenesis, vaccination, and new therapeutic modalities; (2) bone marrow microenvironment and hematopoiesis; (3) cells involved in the pathogenesis of the virus such as: mesenchymal stem cells, dendritic cells, natural killer cells, T-cells and mononuclear cells; (4) cellular proteins such as open reading frames, glycoproteins, promyelocytic leukemia protein, chaperons, and SUMOs; (5) extracellular vesicles, exosomes, and micro-RNAs; and (6) signaling pathways, cytokines, and interferons.</p> 07/05/2019//m.karmaimpex.com/jhcr/jhcr-aid1009.php <h2>Editorial</h2> <p>Varicella zoster virus (VZV), a double-stranded DNA virus, is a highly contagious human neurotropic virus that belongs to the alpha group of herpes viruses [1-4]. Primary VZV infection (chickenpox) occurs in childhood then the virus becomes latent in the nerve ganglia [1,5-7]. Reactivation of the virus may occur decades later and cause herpes zoster (HZ) which is manifested by a typical painful skin eruption that has characteristic dermatomal distribution [1,5]. Reactivation of VZV is usually predisposed to: old age; comorbid medical conditions such as diabetes mellitus, chronic obstructive airway disease, and end-stage renal disease; and immunosuppression due to malignancy, autoimmune disorders, immunosuppressive therapies, trauma, cytotoxic chemotherapy, hematopoietic stem cell transplantation (HSCT), and solid organ transplantation (SOT) [1,5-7].</p> 05/03/2019//m.karmaimpex.com/jhcr/jhcr-aid1008.php & lt; h2> Abstract< / h2>& lt; p> & lt; strong>背景:& lt; / strong>纯红细胞再生障碍性贫血的特点是贫血,reticulocytopenia和减少骨髓红细胞前体细胞。多因子的病因,因此几个治疗干预。;/ p>& lt; p> & lt; strong> Case< / strong>: 2017年8月,一位年轻的病人被诊断为患有纯红细胞再生障碍性贫血。她被免疫抑制治疗大约两个月,但这种治疗停止是因为偏执。后来她接受valacyclovir带状疱疹感染。随后,指出,由于标准化病人输血成为独立的血红蛋白和红细胞前体细胞再生在骨髓。;/ p>& lt; p> & lt; strong> Discussion< / strong>:水痘带状疱疹病毒的行为不同于其他成员的疱疹病毒巨细胞病毒和巴尔病毒等。两个回顾性研究,表现在恶性血液疾病患者和骨髓衰竭,表明感染的病毒可能导致刺激骨髓中的三个细胞株和优越的整体生存。你们;/ p> <p><strong>Conclusion</strong>: The outcome of the patient presented confirms the findings of the two studies showing long-term beneficial effects of varicella zoster virus infections in immunocompromised individuals.</p> 09/17/2018//m.karmaimpex.com/jhcr/jhcr-aid1007.php & lt; h2> Abstract< / h2><p><strong>Background</strong>: Invasive fungal infections cause significant morbidity and mortality in patients with hematologic malignancies and in recipients of hematopoietic stem cell transplantation.</p> <p><strong>Case</strong>: We report a patient with relapsed acute myeloid leukemia who developed disseminated Fusarium infection during the neutropenic period following the salvage cycle of chemotherapy given at King Fahad specialist Hospital in Dammam, Saudi Arabia. The invasive fungal infection was successfully managed with a combination of voriconazole and liposomal amphotericin-B.</p> <p><strong>Discussion</strong>: Fusarium species can cause invasive infections that may become disseminated and life-threatening in patients with acute myeloid leukemia.</p> <p><strong>Conclusion</strong>: Combined antifungal therapy and recovery of neutrophil count are essential to control invasive Fusarium infections.</p> 01/19/2018//m.karmaimpex.com/jhcr/jhcr-aid1006.php & lt; h2> Summary< / h2><p>The effects of Leech Salivary Extract (LSE) on some haematological, immunological and organ weight parameters in rats, during a twenty eight days oral administration of 25, 50 and 100 mg/kg body weight doses, was investigated. LD50 and sub chronic toxicity was determined using standard methods. The oral LD50 was above 5000mg/kgbw. Oral administration of LSE (25mg/kgbw, 50mg/kgbw, 100mg/kgbw) for 28days had no significant (p&gt;0.05) effect on the differential white blood cells (lymphocytes, monocytes, basophils, neutrophils, eosinophils), red blood cell indices (RBC count, PCV, HB, platelets, MCHC and MCH), feed intake, body weight gain and relative organ weight of lung, heart, liver, kidney, spleen and stomach of rats. However, the LSE evoked a significant (p&gt;0.05) increase in the level of MCV in treated rats compared to the control. These results, indicating low toxicity and no negative significant effects of LSE on haemato-immunological indices in rats, suggest that the extract is safe for development and use as therapeutic for managing clinical conditions.</p> 01/19/2018//m.karmaimpex.com/jhcr/jhcr-aid1005.php & lt; h2> Summary< / h2><p><strong>Background and Aims:</strong> the Aim of the study was to find the level of protection among the healthcare workers (nurses, doctors, housekeeping staff and general duty assistants) by doing Anti-HBsAb titer and vaccinate those who were not properly immunized against HBV infection.</p> <p><strong>Materials and Methods:</strong> The study was approved by the Institutional review board of the Hospital. The study group included doctors, nurses, technical staff and lab attendants. Anti-HBs antibody titer was done on Vitros 3600 (OCD, USA). Tests were performed according to manufacturer&rsquo;s instruction. Vaccine provided was Engerix B (GSK Glaxo, Belgium). Vaccination was provided to all employees had titer below 10 miu/ml.</p> <p><strong>Results:</strong> 489 of 794(61.5%) HCW had no history of previous vaccination and only 293 (36.9%) subjects had complete vaccination. Only 60.8 % (482/794) of the total subjects had titer above 10 miu/ml and were protected against Hepatitis B. Around 80.6% (246/305) of those who were fully vaccinated and 40.8% (237/489) of those who were not vaccinated previously had protective anti-HBs titers(&gt;10 miu/ml). Majority (86.8%, 271/312) who had titer below 10 miu/ml were unvaccinated. Two of eight employees who had history of needle stick injury in past were found non-immune to Hepatitis-B infection.</p> <p><strong>Conclusion:</strong> Despite being involved in the procedures with high chances of infections through needle stick or other exposures, only one third of health care workers were vaccinated against hepatitis B. We recommend that all the HCWs should be vaccinated for Hepatitis B and their anti-HBs levels determined at regular intervals.</p> 09/18/2017//m.karmaimpex.com/jhcr/jhcr-aid1004.php & lt; h2> Abstract< / h2><p>An enquiry into the lack of attention awarded to serotonin antagonism in the treatment of arterial thrombosis revealed that the mode of action of serotonin and its platelet receptor antagonists was an action upon thrombus growth, and not, as with other anti-platelet drugs upon the initiation of thrombosis. This lack of effect could explain why this approach has been considered not to be effective. However under conditions of arterial stenosis in which there is platelet activation by increased shear stress, and during the growth phase of arterial thrombi, serotonin 5HT2A antagonism has been demonstrated to have great potentcy in dispersing thrombotic obstruction to blood flow. This mode of action, the lack of participation of serotonin in haemostasis, and the absence of serotonin in wounds accounts for the proven lack of effect of effect of pure specific 5HT2A antagonists (i.e., not those with other actions) on operative bleeding and skin bleeding times. This lack of effect on haemostasis solves the dosing problem encountered with other anti-thrombotic drugs, with which drug concentration cannot be controlled with single fixed doses, leading to the association between increased anti-thrombotic efficacy and increased bleeding complications. Thus 5HT2A antagonism appears to be the preferred approach, from the point of view of safety and lack of bleeding risk; this consideration applies particularly to thrombosis therapy in the context of traumatic accidents, surgical operations and invasive procedures such as angioplasty.</p> 09/12/2017//m.karmaimpex.com/jhcr/jhcr-aid1003.php & lt; h2> Abstract< / h2>& lt; p> & lt; strong>背景:& lt; / strong>Knowledge of pulmonary complications (PCs) in children after hematopoetic stem cell transplantation (allo-HSCT) is limited; most data are from adult studies.</p> <p><strong>Case</strong>: We describe a 8 year old girl with high risk acute myeloid leukemia who developed graft versus host disease (GVHD) on Day 20, Cytomegalovirus (CMV) pneumonia on Day 50 and Cryptogenic organizing pneumonia (COP) on Day 170 after allo-HSCT.</p> <p><strong>Discussion: </strong>Cryptogenic organizing pneumonia is a rare noninfectious PCs that can be idiopathic or have several risk factors as a secondary causes, such as viral respiratory infections, drugs, GVHD and allo-HSCT. Viral respiratory infections and alloimmune lung syndromes have been reported in a few patients who have undergone transplantation.</p> <p><strong>Conclusion:</strong> Transplant physicians should be kept in mind for the development of alloimmune lung syndrome in the form of COP following CMV pneumonia in patients after allo- HSCT</p> 03/30/2017//m.karmaimpex.com/jhcr/jhcr-aid1002.php <h2>Editorial</h2> <p>Lung cancer is the leading cause of cancer-related deaths worldwide, and almost accounts for 20% of these deaths, however, the cure rate is less than 10% [1]. Non-small cell lung cancer (NSCLC) accounts for approximately 85% of all cases of lung cancer [1], but fewer than 15% of individuals diagnosed with NSCLC can survive for more than 5 years, which poses a great threat to the patient&rsquo;s life and health [2]. Recently, the incidence of lung cancer keeps dynamically growing, but more than 75% of patients at diagnosis has appeared local development or metastasis, missing the best period of surgery. Moreover, despite surgical treatment is the optimal choice for early-stage NSCLC patients, 30%-40% of patients with NSCLC develop tumor recurrence in a short time. Therefore, improving the prognosis of patients with lung cancer and predicting the long-term survival of patients is of particular importance [3]. At present, tumor and node metastasis (TNM) staging system, clinicopathological characteristics, visceral pleural invasion and marginal status are used to predict the disease progression and overall survival of NSCLC patients. There is no index which is stable, effective, reliable and less harmful to assess prognosis, predict recurrence risk and overall survival.</p> 01/09/2017//m.karmaimpex.com/jhcr/jhcr-aid1001.php <h2>ABSTRACT</h2> <p>Primary cutaneous lymphomas (PCLs) are the second most common group of extranodal non-Hodgkin lymphomas (NHL) with an estimated annual incidence of 1/100.000. Interferons (IFNs) are used in mono or combination therapy for cutaneous lymphomas especially for cutaneous T-cell lymphomas (CTCL) for years. IFN-&alpha; is the most widely-used type for cutaneous lymphomas. IFN-&alpha; has been shown to be a highly active agent in CTCL with response rates ranging from 40% to 80%. In this review, the current information about PCLs and IFNs treatment is summarized.</p>